Raphaël Frédérick Selected Research

Lactate Dehydrogenases

2/2022	Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade.
1/2021	Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides.
1/2020	Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides.

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Raphaël Frédérick Research Topics

Disease

24	Neoplasms (Cancer) 02/2022 - 02/2011
1	Colitis 01/2022
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022
1	Glioblastoma (Glioblastoma Multiforme) 11/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019
1	Alcoholism (Alcohol Abuse) 01/2019
1	Starvation 12/2016
1	Thrombosis (Thrombus) 03/2016
1	Obesity 01/2016
1	Hypoxia (Hypoxemia) 03/2013
1	Breast Neoplasms (Breast Cancer) 03/2013

Drug/Important Bio-Agent (IBA)

7	EnzymesIBA 02/2022 - 08/2011
5	Serine (L-Serine)FDA Link 07/2021 - 01/2017
4	Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)IBA 07/2021 - 01/2017
3	Lactate DehydrogenasesIBA 02/2022 - 01/2020
3	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 12/2016
3	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 10/2013 - 02/2011
2	Tryptophan Oxygenase (Tryptophan 2,3 Dioxygenase)IBA 01/2022 - 08/2011
2	Pyruvic Acid (Pyruvate)IBA 01/2021 - 12/2016
2	Pharmaceutical PreparationsIBA 01/2019 - 01/2019
2	Glucose (Dextrose)FDA LinkGeneric 04/2017 - 12/2016
2	Harmine (Telepathine)IBA 04/2015 - 07/2012
1	SeleniumIBA 01/2022
1	Nanoparticle Drug Delivery SystemIBA 01/2022
1	Monoclonal AntibodiesIBA 01/2022
1	CytokinesIBA 01/2022
1	Peroxidase (Myeloperoxidase)IBA 01/2022
1	KynurenineIBA 12/2021
1	ProdrugsIBA 11/2021
1	olaparibIBA 11/2021
1	Temozolomide (Temodar)FDA LinkGeneric 11/2021
1	MethyltransferasesIBA 11/2021
1	DNA (Deoxyribonucleic Acid)IBA 11/2021
1	O-(6)-methylguanineIBA 11/2021
1	Oxidoreductases (Dehydrogenase)IBA 07/2021
1	ElementsIBA 01/2021
1	Waste Products (Waste Product)IBA 01/2021
1	Cysteine (L-Cysteine)FDA Link 01/2019
1	Disulfiram (Antabuse)FDA Link 01/2019
1	ArginaseIBA 10/2017
1	phosphoserine aminotransferase (phosphoserine transaminase)IBA 01/2017
1	lactate dehydrogenase 1 (LDH1)IBA 12/2016
1	NAD (NADH)IBA 12/2016
1	Peptide Hydrolases (Proteases)FDA Link 03/2016
1	Factor XIIa (Coagulation Factor XIIa)IBA 03/2016
1	Inulin FDA Link 01/2016
1	Fructans (Levans)IBA 01/2016
1	tyrosine receptor (receptor, tyrosine)IBA 11/2015
1	Phosphotransferases (Kinase)IBA 11/2015
1	Doxorubicin (Adriamycin)FDA LinkGeneric 03/2013
1	Cytotoxins (Cytolysins)IBA 03/2013
1	Carbonic Anhydrases (Carbonic Anhydrase)IBA 03/2013
1	Cytostatic AgentsIBA 07/2012
1	Carbolines (Beta-Carbolines)IBA 07/2012
1	Tryptophan (L-Tryptophan)FDA Link 08/2011
1	Heme (Haem)IBA 02/2011
1	DioxygenasesIBA 02/2011

Therapy/Procedure

9	Therapeutics 02/2022 - 02/2012
3	Immunotherapy 01/2022 - 10/2013